Mevalonate pathway

Production of mevalonate is the rate-limiting and irreversible step in cholesterol synthesis and is the site of action for statins. Acetyl-CoA is coming from Citric Acid Cycle. Mevalonate pathway Acetoacetyl-CoA thiolase Acetoacetyl-CoA thiolase Hydroxymethylglutaryl-CoA synthase or HMG-CoA synthase; EC 2.3.3.10 1xpk HMG-CoA Reductase HMG-CoA Reductase Mevalonate kinase Mevalonate kinase Phosphomevalonate kinase The Crystal Structure of Human Phosphomavelonate Kinase At 1.8 A Resolution 3ch4 Mevalonate-5-pyrophosphate decarboxylase Diphosphomevalonate decarboxylase (EC 4.1.1.33), most commonly referred to in scientific literature as mevalonate diphosphate decarboxylase. Mevalonate Diphosphate Decarboxylase Isopentenyl pyrophosphate isomerase Isopentenyl pyrophosphate isomerase (EC 5.3.3.2, IPP isomerase), also known as Isopentenyl-diphosphate delta isomerase Isopentenyl-diphosphate delta-isomerase Mevalonate is finally converted to isopentenyl pyrophosphate.

spinqualitylabelsall models Human 3-ketoacyl-CoA complex with CoA and ethylene glycol (PDB code 4c2j) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image