Mannose-binding protein

Function Mannose-binding protein (MBL) or Mannose-binding lectin or Mannan-binding lectin is a lectin essential to innate immunity. MBL recognizes carbohydrate patterns like mannose or glucose located on the surface of microorganisms like bacteria, viruses and fungi. MBL binds to the microorganism and the activation of the lectin pathway ensues. MBL binds to apoptotic and senescent cells and enhances their engulfment by phagocytes. In the blood, MBL is bound to MBL-associated serine protease (MASP-2). Upon binding of MBL to a target mannose, the MASP initiates the complement cascade resulting in lysis of the pathogen. Disease MBL deficiency is associated with poor outcome of cystic fibrosis patients. MBL deficiency is one of the most common human immunodeficiencies and arise primarily from 3 single point mutations in the MBL gene. Structural highlights .

spinqualitylabelsall models Rat mannose-binding protein fragment complex with mannose and Ca+2 ion (green), 1kzb Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of mannose-binding protein3D structures of mannose-binding protein

Updated on 03-September-2020

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• mannose-binding protein-a
  • 1hup – hMBL – human
    
  • 1ytt, 1kwt, 1buu, 1rtm - rMBL fragment - rat
    
  • 1kmb, 1fif, 1afd, 2kmb - rMBL fragment (mutant)
    
  • 1msb - rMBL lectin domain
    
  • 3a0c – PcMBL – Polygonatum cyrtonema
    
  • 4akd – MBL – Artocarpus integer
    
  • 4okd – MsMBL – Mycobacterium smegmatis
    
  • 1zhq – MvMBL – Microcystis viridis
    
  • 2y1s – MaMBL – Microcystis aeruginosa - NMR
    
• Mannose-binding protein-a complex with sugar
  • 1rdi, 1rdj, 1rdk, 1rdl, 1rdm, 1rdn, 1rdo, 1kwu, 1kwv, 1kww, 1kwx – rMBL fragment + monosaccharide
    
  • 1fih, 1afa, 1afb, 1bch, 1bcj - rMBL fragment (mutant) + monosaccharide
    
  • 1kwy, 1kx1, 1kza, 1kzd, 1kze - rMBL fragment + bisaccharide
    
  • 1kwz, 1kx0 - rMBL fragment (mutant) + bisaccharide
    
  • 1kzb, 1kzc - rMBL fragment + mannose
    
  • 2msb - rMBL fragment + oligosaccharide
    
  • 3kmb, 4kmb - rMBL fragment (mutant) + oligosaccharide
    
  • 1qmo – MBL + mannose – bean
    
  • 2chh – MBL + alpha-mannose + beta-mannose – Ralstonia solanacearum
    
  • 3a0d, 3a0e – PcMBL + mannose derivative
    
  • 4oit – MsMBL + alpha-mannose + beta-mannose
    
  • 4oiz – MsMBL + methyl-mannose
    
  • 1zhs – MvMBL + ManGlcNac
    
  • 2yhh – MaMBL + alpha-mannose - NMR
    
• Mannose-binding protein-c
  • 1bvr - rMBL subtilisin fragment