Latrophilin

Function Latrophilin (LAT) or adhesion G protein-coupled receptor is the major brain receptor for α-latroxin - a black widow spidertoxin which stimulates strong neuronal exocytosis in vertebrates. LAT is cleaved proteolitically into 2 fragments which reassociate upon binding an agonist and upon reassociation cause release of calcium from intracellular stores and massive release of neurotransmitter. Latrophilin-1 is required for some inhibitory synaptic connections . Latrophilin-3 mediates synapse formation in the hypoccampus. Disease LAT-3 variant confers susceptibility to ADHD and predicts effectiveness of stimulant medication. Structural highlights The high-affinity of the LAT-3/FLRT3 complex is achieved by a combination of interactions between the . .

spinqualitylabelsall models Human latrophilin-3 olfactomedin domain (magenta) complex with leucine-rich repeat transmembrane protein 3 (blue) and Ca+2 ion (green) (PDB code 5cmn) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of latrophilin3D structures of latrophilin

Updated on 10-July-2024

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• Latrophilin-1
  • 4dlq – LAT-1 GAIN and HORMR domains - rat
    
  • 2jx9 – mLAT-1 Gal_lectin domain – mouse - NMR
    
  • 2jxa – mLAT-1 Gal_lectin domain + rhamnose - NMR
    
• Latrophilin-3
  • 5ftt, 5ftu – hLAT-3 + FLRT2 + netrin receptor - human
    
  • 4rmk, 4rml – hLAT-3 olfactomedin domain 199-495
    
  • 5afb – hLAT-3 olfactomedin and lectin domains 97-495
    
  • 5cmn – hLAT-3 olfactomedin domain + FLRT3
    
  • 8djg – hLAT-3 residues 24-126 + antibody
    
  • 7wy5, 7wy8, 7wyb – hLAT-3 + nanobody + GS – Cryo EM
    
  • 7sf7 – hLAT-3 residues 842-1138 + GS – Cryo EM
    
  • 7x10 – hLAT-3 + Scfv + GS – Cryo EM
    
  • 4yeb – mLAT-3 + FLRT3
    
  • 6jbu – mLAT-3 olfactomedin domain + FLRT3
    
  • 6ska, 6ske, 6vhh – mLAT-3 olfactomedin domain + teneurin-2