Insulin-like growth factor

Function

Insulin-like growth factor (IGF) are proteins with high sequence similarity to insulin. IGF are ligands in a complex called the IGF axis, which contains 2 IGF receptors, 6 IGF-binding proteins and IGF-binding protein degrading enzyme^[1].

IGF I is secreted in the liver after stimulation by growth hormone. See details in IGF1 and Igf1 - alec.
IGF II is required in early development stages.

Relevance

Inhibition of IGF I influences colon cancer^[2]. IGF I has protective effect in neuropathy^[3].

Structure of insulin-like growth factor I complex with detergent (PDB entry 1gzr)

Drag the structure with the mouse to rotate

3D structures of insulin-like growth factor3D structures of insulin-like growth factor

Updated on 17-January-2024

ReferencesReferences

↑ Wood AW, Duan C, Bern HA. Insulin-like growth factor signaling in fish. Int Rev Cytol. 2005;243:215-85. PMID:15797461 doi:http://dx.doi.org/10.1016/S0074-7696(05)43004-1
↑ Giovannucci E. Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J Nutr. 2001 Nov;131(11 Suppl):3109S-20S. PMID:11694656
↑ Mohamed-Ali V, Pinkney J. Therapeutic potential of insulin-like growth factor-1 in patients with diabetes mellitus. Treat Endocrinol. 2002;1(6):399-410. PMID:15832492

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Wood AW, Duan C, Bern HA. Insulin-like growth factor signaling in fish. Int Rev Cytol. 2005;243:215-85. PMID:15797461 doi:http://dx.doi.org/10.1016/S0074-7696(05)43004-1

[2] Giovannucci E. Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J Nutr. 2001 Nov;131(11 Suppl):3109S-20S. PMID:11694656

[3] Mohamed-Ali V, Pinkney J. Therapeutic potential of insulin-like growth factor-1 in patients with diabetes mellitus. Treat Endocrinol. 2002;1(6):399-410. PMID:15832492

[1]

[2]

[3]