Indole-3-glycerol phosphate synthase

Function

Indole-3-glycerol phosphate synthase or imidazole glycerol phosphate synthase (IGPS) catalyzes the reversible transformation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate (CdRP) to 1-C-(indol-e-yl)-glycerol 3-phosphate (IGP), CO2 and H2O. IGPS is part of the tryptophan biosynthesis^[1].

Structural highlights

The ^[2]. Water molecules shown as red spheres.

3D structures of IGPS3D structures of IGPS

IGPS 3D structures

ReferencesReferences

↑ Creighton TE, Yanofsky C. Indole-3-glycerol phosphate synthetase of Escherichia coli, an enzyme of the tryptophan operon. J Biol Chem. 1966 Oct 25;241(20):4616-24. PMID:5332729
↑ Hennig M, Darimont BD, Jansonius JN, Kirschner K. The catalytic mechanism of indole-3-glycerol phosphate synthase: crystal structures of complexes of the enzyme from Sulfolobus solfataricus with substrate analogue, substrate, and product. J Mol Biol. 2002 Jun 7;319(3):757-66. PMID:12054868 doi:http://dx.doi.org/10.1016/S0022-2836(02)00378-9

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Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Creighton TE, Yanofsky C. Indole-3-glycerol phosphate synthetase of Escherichia coli, an enzyme of the tryptophan operon. J Biol Chem. 1966 Oct 25;241(20):4616-24. PMID:5332729

[2] Hennig M, Darimont BD, Jansonius JN, Kirschner K. The catalytic mechanism of indole-3-glycerol phosphate synthase: crystal structures of complexes of the enzyme from Sulfolobus solfataricus with substrate analogue, substrate, and product. J Mol Biol. 2002 Jun 7;319(3):757-66. PMID:12054868 doi:http://dx.doi.org/10.1016/S0022-2836(02)00378-9

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