Hypoxia-Inducible factor 1 alpha inhibitor

Function Hypoxia-Inducible factor 1 alpha inhibitor (FIH-1) is an inhibitor of Hypoxia-Inducible Factors 1 alpha (HIF-1). HIF-1 is a master regulator of oxygen homeostasis via transcription activation. Thus, FIH-1 is an inhibitor of transcriptional activation . Relevance The interaction of FIH-1 with notch 1 suggests that it may play a critical role in controlling the survival of vascular endothelial cells and thus may be used in antiangiogenic strategies in controlling cancer and rheumatoid arthritis. FIH-1 acts as a tumor suppressor in human colorectal cancer. Structural highlights (PDB code 1h2m). The 3D structure of the complex between FIH-1 and the C-terminal transactivation domain of HIF-1 shows 2 interaction sites between the two proteins: which includes the which undergoes hydroxylation. .

spinqualitylabelsall models Structure of FIH-1 dimer (cyan, green) complex with HIF-1 C-terminal transactivation domain (pink, magenta), oxalylglycine, sulphate and Zn+2 ion (grey) (PDB code 1h2m) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of Hypoxia-Inducible factor 1 alpha inhibitor3D Structures of Hypoxia-Inducible factor 1 alpha inhibitor

Updated on 30-September-2021

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• Hypoxia-inducible factor 1 alpha inhibitor
  • 1iz3, 1mze, 2cgn, 2cgo – hFIH-1 – human
    
  • 3kcx, 3kcy, 4bio – hFIH-1 + quinoline inhibitor
    
  • 2wa3, 2wa4, 3od4, 4ai8, 5op6, 5op8, 5opc – hFIH-1 + inhibitor
    
  • 1yci – hFIH-1 + Phe derivative
    
  • 1h2n, 1mzf, 2w0x, 2yc0, 2yde, 4z2w, 7a1j, 7a1k, 7a1l, 7a1m – hFIH-1 + glutarate derivative
    
  • 5jwk, 5jwl – hFIH-1 (mutant) + glutarate derivative
    
  • 4z1v – hFIH-1 + oxalylglycine
    
• Hypoxia-inducible factor 1 alpha inhibitor complex with peptide
  • 2xum – hFIH-1 (mutant) + peptide
    
  • 1h2l – hFIH-1 + HIF-1 peptide + glutarate derivative
    
  • 2ilm, 3d8c, 5jwp – hFIH-1 (mutant) + HIF-1 peptide + glutarate derivative
    
  • 2y0i, 7a1s – hFIH-13 + tankyrase-2 peptide + glutarate derivative
    
  • 3p3n, 3p3p – hFIH-1 + notch 1 peptide + glutarate derivative
    
  • 4z1v – hFIH-1 + oxalylglycine
    
  • 1h2k, 1h2m – hFIH-1 + HIF-1 peptide + oxalylglycine
    
  • 6h9j, 6ha6 – hFIH-1 + TRPV3 peptide + oxalylglycine
    
  • 6hc8 – hFIH-1 + TRPA1 peptide + oxalylglycine
    
  • 6hl5, 6hl6 – hFIH-1 + ASPP1 peptide + oxalylglycine
    
  • 6hkp – hFIH-1 + ASPP2 peptide + oxalylglycine
    
  • 4b7e, 4b7k, 4jaa, 4rn1, 6ruj – hFIH-1 + concensus Ankyrin-repeat domain peptide + oxalylglycine
    
  • 7a1n, 7a1o, 7a1p, 7a1q – hFIH-1 + concensus Ankyrin-repeat domain peptide + oxoglutaraste derivative