Haptoglobin receptor

Function Haptoglobin receptor or Iron-regulated surface determinant protein H (IsdH) is part of the iron-regulated surface determinant system that captures heme from the host hemoproteins. IsdH binds haptoglobin (Hp) which removes hemoglobin (Hb) from the blood by forming Hp-Hb complex. IsdH contains multiple NEAT (Near Transporter) domains which bind proteins and heme. For more details see Molecular Playground/Hemoglobin-Haptoglobin Complex. . (PDB code 3szk) . .

spinqualitylabelsall models IsdH NEAT-3 domain (magenta) complex with heme-containing hemoglobin subunits α (green) and β (deepskyblue) (PDB code 3szk) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of haptoglobin receptor3D Structures of haptoglobin receptor

Updated on 27-April-2023

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• IsdH NEAT-1 domain 86-229
  • 2h3k – SaIsdH NEAT-1 domain – Staphylococcus aureus - NMR
    
  • 3ovu – SaIsdH NEAT-1 domain + Hb α + α-Hb-stabilizing protein
    
  • 4wjg – SaIsdH NEAT-1 domain 92-406 + Hb α+β + Hp + Hp-Hb receptor
    
  • 3szk – SaIsdH NEAT-1 domain + Hb α+β
    
  • 3s48 – SaIsdH NEAT-1 domain + Hb α
    
• IsdH NEAT-2 domain 321-464
  • 4fc3 – SaIsdH NEAT-2 domain + Hb α+β
    
• IsdH NEAT-3 domain 539-664
  • 3vua – SaIsdH NEAT-3 domain
    
  • 2z6f – SaIsdH NEAT-3 domain + heme
    
  • 3qug, 3quh, 3vtm – SaIsdH NEAT-3 domain + porphyrin
    
• IsdH NEAT-linker-3 domain 476-656
  • 7w81 – SaIsdH NEAT-linker-3 domain + heme
    
• IsdH NEAT-2-3 domain 326-660
  • 4ij2, 4xs0 – SaIsdH NEAT-2-3 domain (mutant) + Hb α+β
    
• IsdH linker domain 467-543
  • 2lhr – SaIsdH linker domain - NMR