Glutaryl-CoA dehydrogenase

Function Glutaryl-CoA dehydrogenase (GCD) converts glutaryl-CoA to crotonyl-CoA. GCD is part of the metabolism of lysine and tryptophan. See also Acyl-CoA dehydrogenase and Beta oxidation. Disease Defective GCD causes the often fatal glutaric acidemia. The active GCD is a tetramer. Mutations which result in GCD dimers or monomers are associated with glutaric acidemia. Structural highlights The bilogical assembly of GCD from Desulfococcus multivorans is . GCD active site is in a cleft formed by its α,β,α domains. . Water molecules are shown as red spheres.

spinqualitylabelsall models Structure of glutaryl-CoA dehydrogenase complex with FAD and glutaryl-CoA (PDB code 3mpi). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of glutaryl-CoA dehydrogenase3D structures of glutaryl-CoA dehydrogenase

Updated on 15-February-2023

3d6b, 3eom, 3ii9 – BpGCD – Burkholderia pseudomallei
3eon – BpGCD + difluorophenyl methanol
3gqt – BpGCD + quinoxaline derivative
3gnc – BpGCD + piperazine derivative
3mpi – DmGCD + FAD + glutaryl-CoA – Desulfococcus multivorans
3mpj – DmGCD + FAD + peptide
1siq, 1sir – hGCD + FAD - human
2r0m – hGCD (mutant) + FAD + dienolate intermediate
2r0n – hGCD (mutant) + FAD + thiaglutarate-CoA
3sf6, 3swo – GCD + FDA – Mycobacterium smegmatis