Glutaminyl cyclase

Function Glutaminyl cyclase (QC) or glutaminyl-peptide cyclotransferase catalyzes the conversion of glutaminyl-peptide to 5-oxoprolyl-peptide and ammonia. Thus QC catalyzes the cyclization of an N-terminal glutamyl residue. Relevance The biological assembly of Human Glutaminyl cyclase is . QC is considered as a marker of thyroid tumors. QC acts on the generation of N-terminal pyroglutamyl groups of peptide hormones and amyloid-related plaque-forming peptides. The latter contributes to Alzheimer disease. Alzheimer patients show increased expression of QC and QC inhibitors reduces the disease pathology and symptoms. Structural highlights The .

spinqualitylabelsall models Structure of human glutaminyl cyclase complex with benzyimidazole and Zn+2 ion (PDB code 2afx). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of glutaminyl cyclase3D Structures of glutaminyl cyclase

Updated on 16-March-2023

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• Glutaminyl cyclase
  • 2afm, 2afo – hQC – human
    
  • 2afs, 2zed, 2zee, 2zef, 2zeg, 2zeh, 2zel, 2zem, 2zen, 2zeo, 2zep, 3pbe, 4yu9, 7cp0 – hQC (mutant)
    
  • 3pb4, 3pb6 – hQC catalytic domain 28-382
    
  • 3si1 – mQC – mouse
    
  • 4fai, 4fwu, 4f9u – DmQC – Drosophila melanogaster
    
  • 4f9v, 4fbe – DmQC (mutant)
    
  • 2faw – QC – papaya
    
  • 3mbr – QC – Xanthomonas campestris
    
  • 3nol, 3nom – QC – Zymomonas mobilis
    
  • 3nok – QC – Myxococcus xanthus
    
  • 4mhn, 4mhp, 7d1n, 7d1p, 7d1y, 7d21, 7d23, 7d2b, 7d2d, 7d2i, 7d2j – IsQC catalytic domain – Ixodes scapularis
    
  • 7d1h – IsQC catalytic domain (mutant)
    
  • 7d17 – QC – Macrostormum lignano
    
  • 6qql, 7cje, 7cjg – QC – Porphyromonas gingivalis
    
  • 7d18 – QC – Acidobacteriales bacterium
    
  • 7d1b – QC – Fimbrilglobus ruber
    
  • 6qro – QC – Tannerella forsythia
    
• Glutaminyl cyclase complex
  • 2afu – hQC + glutamine t-butyl ester
    
  • 2afw – hQC + N-acetylhistamine
    
  • 2afx, 3si0, 2afz, 3pb9, 7cm0, 7d8e – hQC catalytic domain + imidazole derivative
    
  • 3pb7, 3pb8, 3pbb – hQC catalytic domain + inhibitor
    
  • 4ywy, 6gbx, 7coz – hQC (mutant) + inhibitor
    
  • 6yi1 – hQC + Glu-(γ-hydrazide)-Phe-Ala
    
  • 6yjy – hQC + neurotensin
    
  • 3si2 – mQC + inhibitor
    
  • 7d1d – BtQC + imidazole derivative – Bacterioides thetaiotaomicron
    
  • 7d1e – BtQC + N-acetylhistamine
    
  • 4mhz – IsQC catalytic domain (mutant) + inhibitor
    
  • 4mhy – IsQC catalytic domain + imidazole derivative