Glutamate racemase
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FunctionGlutamate racemase (GR) catalyzes the racemization of L-glutamate to D-glutamate. GR plays a major role in bacterial cell wall biosynthesis and moonlights as gyrase inhibitor[1]. RelevanceGR inhibition is used as anti-bacterial target[2]. Structural highlightsThe is different from that of the . Water molecules shown as red spheres. The latter site is occupied in the native GR by side chains of the enzyme[3] 3D Structures of glutamate racemaseGlutamate racemase 3D structures
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ReferencesReferences
- ↑ Sengupta S, Ghosh S, Nagaraja V. Moonlighting function of glutamate racemase from Mycobacterium tuberculosis: racemization and DNA gyrase inhibition are two independent activities of the enzyme. Microbiology. 2008 Sep;154(Pt 9):2796-803. doi: 10.1099/mic.0.2008/020933-0. PMID:18757813 doi:http://dx.doi.org/10.1099/mic.0.2008/020933-0
- ↑ Basarab GS, Hill P, Eyermann CJ, Gowravaram M, Kack H, Osimoni E. Design of inhibitors of Helicobacter pylori glutamate racemase as selective antibacterial agents: Incorporation of imidazoles onto a core pyrazolopyrimidinedione scaffold to improve bioavailabilty. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5600-7. Epub 2012 Jul 20. PMID:22877632 doi:http://dx.doi.org/10.1016/j.bmcl.2012.07.004
- ↑ Lundqvist T, Fisher SL, Kern G, Folmer RH, Xue Y, Newton DT, Keating TA, Alm RA, de Jonge BL. Exploitation of structural and regulatory diversity in glutamate racemases. Nature. 2007 Jun 14;447(7146):817-22. PMID:17568739 doi:http://dx.doi.org/10.1038/nature05689