Glucocorticoid receptor 3D structures

3D structures of glucocorticoid receptor3D structures of glucocorticoid receptor

Updated on 14-March-2023

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• Glucocorticoid receptor
  • 7kw7 - hGCR + Hsp90 + Hsp70 + HOP – human – Cryo EM
    
• Glucocorticoid receptor residues 89-158
  • 5va7, 5va0 - hGCR + DNA
    
• Glucocorticoid receptor DBD domain residues 391-480
  • 6cfn - hGCR DBD
    
  • 4hn5, 4hn6, 5emp, 5emq, 5emc, 5e69, 5e6a, 5e6b, 5e6c, 5e6d, 5cbx, 5cby, 5cbz, 6bqu, 6x6d, 6x6e - hGCR DBD + DNA
    
  • 5cc1 - hGCR DBD (mutant) + DNA
    
  • 1gdc, 2gda, 1rgd – rGCR DBD – NMR – rat
    
  • 3g9p, 3fyl, 3g6p, 3g6q, 3g6r, 3g6t, 3g6u, 3g8u, 3g8x, 3g97, 3g99, 3g9i, 3g9m, 3g9j, 3g9o, 1glu, 1lat, 1r4o, 1r4r - rGCR DBD + DNA
    
  • 6bse, 6bsf - GCR DBD + DNA – cotton-top tamarin
    
• Glucocorticoid receptor LBD domain residues 500-777 complex with NCOA peptide
  • 4mdd - hGCR LBD (mutant) + NCOA1 peptide + non-steroidal agonist
    
  • 3h52 - hGCR LBD (mutant) + NCOA1 peptide + steroid
    
  • 4udc, 4udd - hGCR LBD (mutant) + NCOA2 peptide
    
  • 1m2z, 3cld, 3bqd, 4lsj, 4p6w, 4p6x, 1p93 - hGCR LBD (mutant) + NCOA2 peptide + steroid
    
  • 3e7c, 4csj, 5g3j, 5g5w, 5g3j - hGCR LBD (mutant) + NCOA2 peptide + non-steroidal agonist
    
  • 3k23 - hGCR LBD (mutant) + NCOA2 peptide + prolinamide
    
  • 6el9, 6el6, 6el7, 5nft - hGCR LBD + NCOA2 peptide + modulator
    
  • 5nfp, 6w9m - hGCR LBD + NCOA2 peptide + drug
    
  • 3gn8 - hGCR LBD + NCOA2 peptide + steroid
    
  • 4e2j - anGCR LBD + NCOA2 peptide + steroid - ancestral
    
  • 3mne, 3mno, 3mnp - GCR LBD (mutant) + NCOA2 peptide + steroid – mouse
    
• Glucocorticoid receptor LBD domain other complexes
  • 3ry9 - anGCR LBD ancestral + steroid
    
  • 1nhz – hGCR LBD (mutant) + steroid
    
  • 5uc3 - hGCR LBD (mutant) + RU-486
    
  • 3k22 - hGCR LBD (mutant) + transcriptional intermediary factor 2 peptide + alaninamide
    
  • 7krj - hGCR LBD (mutant) + Hsp90 + P23 – Cryo EM
    
  • 6dxk – hGCR LBD + antagonist
    
  • 7prx – hGCR LBD + PGC1A coactivator + modulator
    
  • 7prw – hGCR LBD + PGC1A coactivator + modulator + DNA
    
  • 7prv – hGCR LBD + PGC1A coactivator + DNA + drug
    
• Glucocorticoid receptor 2
  • 5ufs – anGCR2 LBD + SHP coregulatory + triamcinolone acetonide
    
  • 4e2j – anGCR2 LBD ancestral + NCOA2 peptide + steroid
    
  • 6nwl – anGCR2 LBD ancestral + cortisol + PPARGC peptide
    
  • 6nwk, 6w9k, 6w9l – anGCR2 LBD ancestral + drug + PPARGC peptide
    
  • 5uc1 – GCR2 LBD + RU-486 – Heterocephalus glaber