Galactoside O-acetyltransferase

Function

Galactoside O-acetyltransferase (GAT) assists cellular detoxification by acetylating the 6-hydroxyl group of nonmetabolizable pyranosides like galactosides, glucosides and lactosides and thus preventing their reentry into the cell^[1]. GAT gene is part of the lac operon^[2].

Structural highlights

The structure of the complex of GAT with ^[1]. Water molecule shown as red sphere.

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Galactoside O-acetyltransferase complex with acetyl-CoA (PDB code 1krr)

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3D structures of galactoside O-acetyltransferase3D structures of galactoside O-acetyltransferase

Updated on 10-December-2018

1kqa, 1krr – EcGAT + Acetyl CoA – Escherichia coli
1kru, 1krv – EcGAT + Acetyl CoA + galactopyranose derivative
3ftt – SaGAT – Staphylococcus aureus
3v4e, 5u2k, 5v0z – SaGAT + Acetyl CoA
3vbi – BcGAT + Acetyl CoA + TDP derivative – Bacillus cereus
3vbn, 3vbp, 3vbk, 3vbl, 3vbm – BcGAT (mutant) + Acetyl CoA + TDP derivative
3vbj – BcGAT + butyryl CoA + TDP

ReferencesReferences

↑ ^1.0 ^1.1 Wang XG, Olsen LR, Roderick SL. Structure of the lac operon galactoside acetyltransferase. Structure. 2002 Apr;10(4):581-8. PMID:11937062
↑ Roderick SL. The lac operon galactoside acetyltransferase. C R Biol. 2005 Jun;328(6):568-75. doi: 10.1016/j.crvi.2005.03.005. PMID:15950163 doi:http://dx.doi.org/10.1016/j.crvi.2005.03.005

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[GAT-1] 1.0 ^1.1 Wang XG, Olsen LR, Roderick SL. Structure of the lac operon galactoside acetyltransferase. Structure. 2002 Apr;10(4):581-8. PMID:11937062

[2] Roderick SL. The lac operon galactoside acetyltransferase. C R Biol. 2005 Jun;328(6):568-75. doi: 10.1016/j.crvi.2005.03.005. PMID:15950163 doi:http://dx.doi.org/10.1016/j.crvi.2005.03.005

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