Dihydrolipoamide acetyltransferase

Dihydrolipoamide acetyltransferase (DLAT) or E2 is part of the pyruvate dehydrogenase complex together with pyruvate dehydrogenase (E1) and dihydrolipoyl dehydrogenase (E3). The complex decarboxylates pyruvate thus linking the glycolysis to the citric acid cycle. DLAT catalyzes the transfer of acetyl group to CoA.^[1]

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(PDB entry 3rnm), water molecules shown as red spheres.

Human dihydrolipoamide acetyltransferase binding domain (cyan, green) complex with E3 binding domain (magenta), FAD, CHES and mercaptodthanol (PDB entry 3rnm)

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3D structures of dihydrolipoamide acetyltransferase3D structures of dihydrolipoamide acetyltransferase

Dihydrolipoamide acetyltransferase 3D structures

ReferencesReferences

↑ Lai WL, Chou LY, Ting CY, Kirby R, Tsai YC, Wang AH, Liaw SH. The functional role of the binuclear metal center in D-aminoacylase: one-metal activation and second-metal attenuation. J Biol Chem. 2004 Apr 2;279(14):13962-7. Epub 2004 Jan 21. PMID:14736882 doi:http://dx.doi.org/10.1074/jbc.M308849200

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Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Lai WL, Chou LY, Ting CY, Kirby R, Tsai YC, Wang AH, Liaw SH. The functional role of the binuclear metal center in D-aminoacylase: one-metal activation and second-metal attenuation. J Biol Chem. 2004 Apr 2;279(14):13962-7. Epub 2004 Jan 21. PMID:14736882 doi:http://dx.doi.org/10.1074/jbc.M308849200

[1]

Dihydrolipoamide acetyltransferase

3D structures of dihydrolipoamide acetyltransferase3D structures of dihydrolipoamide acetyltransferase

ReferencesReferences

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