Deoxycytidine kinase

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Function

Deoxycytidine kinase (DCK) is required for the phosphorylation of deoxyribonucleosides dC, dG and dA (but not dT and dU) and nucleosides analogs which are used as antiviral and chemotherapeutic agents. [1]

Relevance

Deficiency of DCK causes resistance to antiviral and chemotherapeutic agents.

Structural highlights

The ability of (active site glutamates are in yellow).[2]

3D Structures of deoxycytidine kinase

Deoxycytidine kinase 3D structures


Mouse deoxycytidine kinase complex with ADP and deoxycytidine (PDB entry 1p61)

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ReferencesReferences

  1. ↑ Hazra S, Ort S, Konrad M, Lavie A. Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues . Biochemistry. 2010 Aug 10;49(31):6784-90. PMID:20614893 doi:10.1021/bi100839e
  2. ↑ Sabini E, Ort S, Monnerjahn C, Konrad M, Lavie A. Structure of human dCK suggests strategies to improve anticancer and antiviral therapy. Nat Struct Biol. 2003 Jul;10(7):513-9. PMID:12808445 doi:http://dx.doi.org/10.1038/nsb942

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