D-xylose isomerase

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Function

D-xylose isomerase (DXI) catalyzes the conversion of D-xylose (DX) to D-xylitol. DXI is part of the fructose and mannose metabolism pathways. Sorbitol is a competitive inhibitor of DXI. DXI is a metal-ion activated tetramer.[1]

Relevance

DXI is used commercially in the production of high fructose corn syrup.

Structural highlights

from Arthrobacter sp is homotetramer. DXI active site contains and the (water molecules shown as red spheres).[2]

3D structures of D-xylose isomerase

D-xylose isomerase 3D structures


Structure of D-xylose isomerase complex with D-xylose and Mn+2 ions (purple) (PDB code 1xld).

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ MARSHALL RO, KOOI ER. Enzymatic conversion of D-glucose to D-fructose. Science. 1957 Apr 5;125(3249):648-9. PMID:13421660
  2. ↑ Collyer CA, Henrick K, Blow DM. Mechanism for aldose-ketose interconversion by D-xylose isomerase involving ring opening followed by a 1,2-hydride shift. J Mol Biol. 1990 Mar 5;212(1):211-35. PMID:2319597

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