Cytochrome c oxidase

Function

Cytochrome c oxidase (CcO) is a transmembrane protein complex found in bacteria and mitochondria. CcO is the last enzyme in the electron transport chain. ^[1]

Ba3-type cytochrome c oxidase substrate is cytochrome c552 ^[2].

Disease

CcO deficiency is a genetic condition which affects muscle weakness, muscle tone upto severe brain dysfunction in severe cases.

Structural highlights

Mammalian CcO is composed of , , and cytochrome a and a3. The fully oxidized form of molecule. . ^[3] Bacterial CcO is composed of 2 subunits.

3D Structures of Cytochrome c oxidase

Cytochrome c oxidase 3D structures

Bovine cytochrome c oxidase. Homodimer with 13 subunits (PDB entry 2occ)

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Tsukihara T, Aoyama H, Yamashita E, Tomizaki T, Yamaguchi H, Shinzawa-Itoh K, Nakashima R, Yaono R, Yoshikawa S. Structures of metal sites of oxidized bovine heart cytochrome c oxidase at 2.8 A. Science. 1995 Aug 25;269(5227):1069-74. PMID:7652554
↑ Soulimane T, Buse G, Bourenkov GP, Bartunik HD, Huber R, Than ME. Structure and mechanism of the aberrant ba(3)-cytochrome c oxidase from thermus thermophilus. EMBO J. 2000 Apr 17;19(8):1766-76. PMID:10775261 doi:10.1093/emboj/19.8.1766
↑ Yoshikawa S, Shinzawa-Itoh K, Nakashima R, Yaono R, Yamashita E, Inoue N, Yao M, Fei MJ, Libeu CP, Mizushima T, Yamaguchi H, Tomizaki T, Tsukihara T. Redox-coupled crystal structural changes in bovine heart cytochrome c oxidase. Science. 1998 Jun 12;280(5370):1723-9. PMID:9624044

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[1] Tsukihara T, Aoyama H, Yamashita E, Tomizaki T, Yamaguchi H, Shinzawa-Itoh K, Nakashima R, Yaono R, Yoshikawa S. Structures of metal sites of oxidized bovine heart cytochrome c oxidase at 2.8 A. Science. 1995 Aug 25;269(5227):1069-74. PMID:7652554

[2] Soulimane T, Buse G, Bourenkov GP, Bartunik HD, Huber R, Than ME. Structure and mechanism of the aberrant ba(3)-cytochrome c oxidase from thermus thermophilus. EMBO J. 2000 Apr 17;19(8):1766-76. PMID:10775261 doi:10.1093/emboj/19.8.1766

[3] Yoshikawa S, Shinzawa-Itoh K, Nakashima R, Yaono R, Yamashita E, Inoue N, Yao M, Fei MJ, Libeu CP, Mizushima T, Yamaguchi H, Tomizaki T, Tsukihara T. Redox-coupled crystal structural changes in bovine heart cytochrome c oxidase. Science. 1998 Jun 12;280(5370):1723-9. PMID:9624044

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