Corticosteroids

Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are involved in a wide range of physiological processes.

and its derivatives have some mineralocorticoid action in addition to the glucocorticoid effect.

(hydrocortisone) is a corticosteroid with both glucocorticoid and mineralocorticoid activity and effects.

is a glucocorticoid medication. It is the most potent glucocorticoid and it has not mineralocorticoid potency. (1m2z).

Glucocorticoids
Mineralocorticoids
Pentaerythritol tetranitrate reductase active site contains the cofactor and the ^[1]. Water molecules are shown as red spheres. .
Corticosteroid-binding globulin

FMN containing pentaerythritol tetranitrate reductase complex with prednisone (PDB entry 1h61)

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ReferencesReferences

↑ Barna TM, Khan H, Bruce NC, Barsukov I, Scrutton NS, Moody PC. Crystal structure of pentaerythritol tetranitrate reductase: "flipped" binding geometries for steroid substrates in different redox states of the enzyme. J Mol Biol. 2001 Jul 6;310(2):433-47. PMID:11428899 doi:10.1006/jmbi.2001.4779

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Alexander Berchansky

[1] Barna TM, Khan H, Bruce NC, Barsukov I, Scrutton NS, Moody PC. Crystal structure of pentaerythritol tetranitrate reductase: "flipped" binding geometries for steroid substrates in different redox states of the enzyme. J Mol Biol. 2001 Jul 6;310(2):433-47. PMID:11428899 doi:10.1006/jmbi.2001.4779

[1]

Corticosteroids

ReferencesReferences

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