Carbonyl reductase

Carbonyl reductase (CBR) catalyzes the reaction converting R-CHOH-R and NADP to R-CO-R’ and NADPH. CBR has wide substrate specificity oxidoreductase activity. CBR has similar properties to aldose reductase and aldehyde reductase.

(R)-specific carbonyl reductase yields (R)-alcohols and its cofactor is Zn+2 ion.^[1]
of mouse carbonyl reductase (1cyd).^[2]

3D structures of carbonyl reductase

Carbonyl reductase 3D structures

Mouse carbonyl reductase tetramer complex with 2-propanol and NADPH, 1cyd

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Forrest GL, Gonzalez B. Carbonyl reductase. Chem Biol Interact. 2000 Dec 1;129(1-2):21-40. PMID:11154733
↑ Tanaka N, Nonaka T, Nakanishi M, Deyashiki Y, Hara A, Mitsui Y. Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family. Structure. 1996 Jan 15;4(1):33-45. PMID:8805511

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Michal Harel, Alexander Berchansky

[1] Forrest GL, Gonzalez B. Carbonyl reductase. Chem Biol Interact. 2000 Dec 1;129(1-2):21-40. PMID:11154733

[2] Tanaka N, Nonaka T, Nakanishi M, Deyashiki Y, Hara A, Mitsui Y. Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family. Structure. 1996 Jan 15;4(1):33-45. PMID:8805511

[1]

[2]

Carbonyl reductase

3D structures of carbonyl reductase

ReferencesReferences

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