CD69

From Proteopedia
Jump to navigation Jump to search


CD69 (Cluster of Differentiation 69) is a human transmembrane calcium-dependent lectin protein. CD69 functions as a signal-transmitting receptor in lymphocytes natural killer cells and platelets. CD69 expression is induced upon activation of T-cell lymphocytes. [1] of CD69 extracellular domain dimer complex.[2] Water molecules are shown as red spheres.

Structure of human CD69 extracellular domain dimer complex with Cl- (green) and Na+ (purple) ions (PDB entry 3hup)

Drag the structure with the mouse to rotate

3D structures of CD693D structures of CD69

Updated on 20-January-2025

1e87, 1e8i, 1fm5, 3cck, 3hup – hCD69 extracellular domain 70-199 – human
8g94 – hCD69 + S1PR1 + Gi proteins + ScfV – Cryo EM

ReferencesReferences

  1. ↑ Natarajan K, Sawicki MW, Margulies DH, Mariuzza RA. Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells. Biochemistry. 2000 Dec 5;39(48):14779-86. PMID:11101293
  2. ↑ Kolenko P, Skalova T, Vanek O, Stepankova A, Duskova J, Hasek J, Bezouska K, Dohnalek J. The high-resolution structure of the extracellular domain of human CD69 using a novel polymer. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt, 12):1258-60. Epub 2009 Nov 27. PMID:20054122 doi:10.1107/S1744309109043152

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=CD69&oldid=4216222"