Blue copper oxidase CueO
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FunctionBlue copper oxidase CueO (CueO) or laccase CueO is an E. coli enzyme which catalyzes the conversion of Cu+1 to Cu+2 resulting in the detoxification of copper by the prevention of its uptake into the cytoplasm.[1] RelevanceCueO is involved in prevention of oxidative damage in the periplasm. Structural highlightsThe Cu moieties (Cu-O-Cu and Cu+2) are coordinated by at least 2 histidine residues: and .[2] 3D structures of blue copper oxidase CueOBlue copper oxidase CueO 3D structures
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ReferencesReferences
- ↑ Grass G, Rensing C. CueO is a multi-copper oxidase that confers copper tolerance in Escherichia coli. Biochem Biophys Res Commun. 2001 Sep 7;286(5):902-8. PMID:11527384 doi:http://dx.doi.org/10.1006/bbrc.2001.5474
- ↑ Li X, Wei Z, Zhang M, Peng X, Yu G, Teng M, Gong W. Crystal structures of E. coli laccase CueO at different copper concentrations. Biochem Biophys Res Commun. 2007 Mar 2;354(1):21-6. Epub 2006 Dec 22. PMID:17217912 doi:10.1016/j.bbrc.2006.12.116