Blue copper oxidase CueO

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Function

Blue copper oxidase CueO (CueO) or laccase CueO is an E. coli enzyme which catalyzes the conversion of Cu+1 to Cu+2 resulting in the detoxification of copper by the prevention of its uptake into the cytoplasm.[1]

Relevance

CueO is involved in prevention of oxidative damage in the periplasm.

Structural highlights

The Cu moieties (Cu-O-Cu and Cu+2) are coordinated by at least 2 histidine residues: and .[2]

3D structures of blue copper oxidase CueO

Blue copper oxidase CueO 3D structures


Structure of E. coli blue copper oxidase CueO complex with two Cu+2 ions (orange), Cu-O-Cu and citrate (PDB code 2fqf).

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ReferencesReferences

  1. Grass G, Rensing C. CueO is a multi-copper oxidase that confers copper tolerance in Escherichia coli. Biochem Biophys Res Commun. 2001 Sep 7;286(5):902-8. PMID:11527384 doi:http://dx.doi.org/10.1006/bbrc.2001.5474
  2. Li X, Wei Z, Zhang M, Peng X, Yu G, Teng M, Gong W. Crystal structures of E. coli laccase CueO at different copper concentrations. Biochem Biophys Res Commun. 2007 Mar 2;354(1):21-6. Epub 2006 Dec 22. PMID:17217912 doi:10.1016/j.bbrc.2006.12.116

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