Anti-sigma factor antagonist

Anti-sigma factor antagonist (SPOIIAA) relieves the inhibition of sigma factor by the anti-sigma factor. The sigma factors (see Sigma factor) are transcriptional regulators whose activity is regulated by anti-sigma factor proteins. The latters are regulated by the anti-sigma factor antagonists.^[1]

Structural highlights

of Anti-sigma factor antagonist with anti-sigma factor, Mg+2 ion and ADP.
(1th8).^[2] Water molecules are shown as red spheres.
Anti-sigma factor antagonist contains STAS domain. See STAS domain of the SLC26 anion transporter prestin.

3D Structures of anti-sigma factor antagonist

Anti-sigma factor antagonist 3D structures

Anti-sigma factor antagonist (cyan) complex with anti-sigma factor (magenta), Mg+2 ion and ADP (PDB code 1th8)

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Seavers PR, Lewis RJ, Brannigan JA, Verschueren KH, Murshudov GN, Wilkinson AJ. Structure of the Bacillus cell fate determinant SpoIIAA in phosphorylated and unphosphorylated forms. Structure. 2001 Jul 3;9(7):605-14. PMID:11470435
↑ Masuda S, Murakami KS, Wang S, Anders Olson C, Donigian J, Leon F, Darst SA, Campbell EA. Crystal structures of the ADP and ATP bound forms of the Bacillus anti-sigma factor SpoIIAB in complex with the anti-anti-sigma SpoIIAA. J Mol Biol. 2004 Jul 23;340(5):941-56. PMID:15236958 doi:10.1016/j.jmb.2004.05.040

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Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Seavers PR, Lewis RJ, Brannigan JA, Verschueren KH, Murshudov GN, Wilkinson AJ. Structure of the Bacillus cell fate determinant SpoIIAA in phosphorylated and unphosphorylated forms. Structure. 2001 Jul 3;9(7):605-14. PMID:11470435

[2] Masuda S, Murakami KS, Wang S, Anders Olson C, Donigian J, Leon F, Darst SA, Campbell EA. Crystal structures of the ADP and ATP bound forms of the Bacillus anti-sigma factor SpoIIAB in complex with the anti-anti-sigma SpoIIAA. J Mol Biol. 2004 Jul 23;340(5):941-56. PMID:15236958 doi:10.1016/j.jmb.2004.05.040

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[2]

Anti-sigma factor antagonist

Structural highlights

3D Structures of anti-sigma factor antagonist

ReferencesReferences

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