Alpha-tubulin N-acetyltransferase
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Alpha-tubulin N-acetyltransferase (TAT) catalyzes the conversion of acetyl-CoA and tubulin-L-lysine to CoA and tubulin-N-acetyl-L-lysine. TAT acetylates Lys40 in tubulin and is required for normal sperm flagellar function. This posttranslational modification of tubulin is conserved in long-lived microtubules. TAT can acetylate itself and this acts as a regulatory mechanism for its action on tubulin.[1] of α-tubulin N-acetyltransferase (PDB code 3vwe).[2] Water molecules are shown as red spheres. 3D Structures of alpha-tubulin N-acetyltransferaseAlpha-tubulin N-acetyltransferase 3D structures
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ReferencesReferences
- ↑ Friedmann DR, Aguilar A, Fan J, Nachury MV, Marmorstein R. Structure of the alpha-tubulin acetyltransferase, alphaTAT1, and implications for tubulin-specific acetylation. Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19655-60. doi:, 10.1073/pnas.1209357109. Epub 2012 Oct 15. PMID:23071314 doi:10.1073/pnas.1209357109
- ↑ Akella JS, Wloga D, Kim J, Starostina NG, Lyons-Abbott S, Morrissette NS, Dougan ST, Kipreos ET, Gaertig J. MEC-17 is an alpha-tubulin acetyltransferase. Nature. 2010 Sep 9;467(7312):218-22. doi: 10.1038/nature09324. PMID:20829795 doi:10.1038/nature09324