APT synthase

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APT synthase (ATPS) synthesizes the formation of ATP from ADP and phosphate.  ATPS is a multi-subunit structure that works like  en electron gradient pump across mitochondrial membrane [1].

Function

ATPS via ATP formation provides most of the cellular energy needed for bodily functions.

Disease

Mutations in ATPS result in a variety of encephalo- and cardiomyopathies of mitochondrial or nuclear origin[2].

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Structural highlights

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Caption for this structure

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ReferencesReferences

  1. Neupane P, Bhuju S, Thapa N, Bhattarai HK. ATP Synthase: Structure, Function and Inhibition. Biomol Concepts. 2019 Mar 7;10(1):1-10. doi: 10.1515/bmc-2019-0001. PMID:30888962 doi:http://dx.doi.org/10.1515/bmc-2019-0001
  2. Galber C, Carissimi S, Baracca A, Giorgio V. The ATP Synthase Deficiency in Human Diseases. Life (Basel). 2021 Apr 8;11(4). pii: life11040325. doi: 10.3390/life11040325. PMID:33917760 doi:http://dx.doi.org/10.3390/life11040325

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Michal Harel