AMP-activated protein kinase 3D structures

3D structures of AMP-activated protein kinase3D structures of AMP-activated protein kinase

Updated on 29-September-2024

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• AMPK α-1 subunit
  • 4red - hAMPK α1 subunit (mutant) - human
    
  • 4f2l - rAMPK α1 subunit – rat
    
• AMPK α-2 subunit
  • 2h6d - hAMPK α2 subunit
    
  • 2ltu - hAMPK α2 subunit – NMR
    
  • 2yza - hAMPK α2 subunit (mutant)
    
  • 3aqv - hAMPK α2 subunit (mutant) + inhibitor
    
  • 6bx6 – hAMPK kinase domain (mutant) + inhibitor
    
• AMPK β-1 carbohydrate-binding domain
  • 1z0m, 4yef – rAMPK + β-cyclodextrin - rat
    
  • 1z0n – rAMPK (mutant) + β-cyclodextrin
    
  • 4yef – rAMPK + glucosyl-cyclodextrin
    
• AMPK β-2 carbohydrate-binding domain
  • 2f15 – hAMPK
    
  • 2lu3 – rAMPK - NMR
    
  • 2lu4 – rAMPK + glycosyl-cyclodextrin - NMR
    
  • 4y0g – rAMPK
    
  • 4yee – rAMPK + glycosyl-cyclodextrin
    
• AMPK γ-1 subunit
  • 2uv4, 2uv5 - hAMPK CBS 3+4 domains + AMP
    
  • 2uv6, 2uv7 - hAMPK CBS 3+4 domains (mutant) + AMP
    
• AMPK α-1+β-2+γ-1
  • 2v8q, 4eai – rAMPK + AMP
    
  • 2v92, 2v9j, 4eaj – rAMPK + AMP + ATP
    
  • 2y8l, 2y8q – rAMPK + ADP
    
  • 2ya3 – rAMPK + coumarin-ADP + AMP
    
  • 4rew – hAMPK (mutant) + AMP
    
• AMPK α-1+β-1+γ-1
  • 4eal – rAMPK + AMP
    
  • 4eak – rAMPK + ATP
    
  • 4eag – SNF1A/rAMPK β-1 γ-1 + ATP
    
• Phosphorylated AMPK α-1+β-2+γ-1
  • 7jij, 7m74 – hAMPK + AMP + ADP + ATP
    
  • 7jhh – hAMPK + AMP + ADP + ATP + nanobody – Cryo EM
    
  • 7jhg – hAMPK + AMP + ADP + ATP + inhibitor + nanobody – Cryo EM
    
  • 4rer – hAMPK (mutant) + AMP + staurosporine + cyclodextrin
    
  • 4cfh – rAMPK + AMP + staurosporine
    
• Phosphorylated AMPK α-1+β-1+γ-1
  • 6c9f – hAMPK + activator
    
  • 6c9g, 6c9h, 6c9j – hAMPK (mutant) + activator
    
  • 4qfg – rAMPK (mutant) + AMP + staurosporine
    
  • 5ufu, 6e4u, 6e4t, 6e4w – rAMPK + AMP + ADP + staurosporine + activator
    
  • 4qfr, 4qfs, 5t5t – rAMPK (mutant) + AMP + ADP + staurosporine + activator
    
  • 5kq5 – rAMPK + AMP + ADP + staurosporine + activator
    
• Phosphorylated AMPK α-2+β-1+γ-1
  • 4cfe, 5iso, 4cff, 6b1u, 7myj, 8bik – hAMPK + AMP + staurosporine + benzimidazole derivative
    
  • 4zhx, 5ezv – hAMPK + AMP + staurosporine + furan-2-posphonic derivative
    
• Phosphorylated AMPK α-2+β-2+γ-1
  • 6b2e – hAMPK + AMP + staurosporine + activator