9az4

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INF2 at the Barbed End of F-ActinINF2 at the Barbed End of F-Actin

Structural highlights

9az4 is a 8 chain structure with sequence from Homo sapiens and Oryctolagus cuniculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.37Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

INF2_HUMAN Autosomal dominant intermediate Charcot-Marie-Tooth disease type E;Genetic steroid-resistant nephrotic syndrome. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.

Function

INF2_HUMAN Severs actin filaments and accelerates their polymerization and depolymerization.

9az4, resolution 3.37Å

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OCA