8yx6

Structure of a Cys-loop Receptor in Zinc Binding StateStructure of a Cys-loop Receptor in Zinc Binding State

Structural highlights

8yx6 is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 2.9Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ZACN_HUMAN Ligand-gated cation channel that allows the movement of sodium and potassium monoatomic cations across cell membranes when activated by zinc (Zn2+), copper (Cu2+), and changes in pH (PubMed:26872532). Could also transport cesium (PubMed:26872532).^[1]

References

↑ Trattnig SM, Gasiorek A, Deeb TZ, Ortiz EJ, Moss SJ, Jensen AA, Davies PA. Copper and protons directly activate the zinc-activated channel. Biochem Pharmacol. 2016 Mar 1;103:109-17. PMID:26872532 doi:10.1016/j.bcp.2016.02.004

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OCA

[1] Trattnig SM, Gasiorek A, Deeb TZ, Ortiz EJ, Moss SJ, Jensen AA, Davies PA. Copper and protons directly activate the zinc-activated channel. Biochem Pharmacol. 2016 Mar 1;103:109-17. PMID:26872532 doi:10.1016/j.bcp.2016.02.004

[1]

8yx6

Structure of a Cys-loop Receptor in Zinc Binding StateStructure of a Cys-loop Receptor in Zinc Binding State

Structural highlights

Function

References

Contents

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8yx6

Structure of a Cys-loop Receptor in Zinc Binding StateStructure of a Cys-loop Receptor in Zinc Binding State

Structural highlights

Function

References

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