8ynt

Cryo-EM structure of SNAP-94847-bound MCHR1, S2 stateCryo-EM structure of SNAP-94847-bound MCHR1, S2 state

Structural highlights

8ynt is a 4 chain structure with sequence from Escherichia coli, Homo sapiens, Pan paniscus and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.43Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

C562_ECOLX Electron-transport protein of unknown function.A0A2R9AFP0_PANPA MCHR1_HUMAN Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.^[1] ^[2]

References

↑ Chambers J, Ames RS, Bergsma D, Muir A, Fitzgerald LR, Hervieu G, Dytko GM, Foley JJ, Martin J, Liu WS, Park J, Ellis C, Ganguly S, Konchar S, Cluderay J, Leslie R, Wilson S, Sarau HM. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature. 1999 Jul 15;400(6741):261-5. PMID:10421367 doi:10.1038/22313
↑ Hawes BE, Green B, O'Neill K, Fried S, Arreaza MG, Qiu P, Simon JS. Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2. Obes Res. 2004 Aug;12(8):1327-34. PMID:15340116 doi:10.1038/oby.2004.167

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OCA

[1] Chambers J, Ames RS, Bergsma D, Muir A, Fitzgerald LR, Hervieu G, Dytko GM, Foley JJ, Martin J, Liu WS, Park J, Ellis C, Ganguly S, Konchar S, Cluderay J, Leslie R, Wilson S, Sarau HM. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature. 1999 Jul 15;400(6741):261-5. PMID:10421367 doi:10.1038/22313

[2] Hawes BE, Green B, O'Neill K, Fried S, Arreaza MG, Qiu P, Simon JS. Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2. Obes Res. 2004 Aug;12(8):1327-34. PMID:15340116 doi:10.1038/oby.2004.167

[1]

[2]

8ynt

Cryo-EM structure of SNAP-94847-bound MCHR1, S2 stateCryo-EM structure of SNAP-94847-bound MCHR1, S2 state

Structural highlights

Function

References

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8ynt

Cryo-EM structure of SNAP-94847-bound MCHR1, S2 stateCryo-EM structure of SNAP-94847-bound MCHR1, S2 state

Structural highlights

Function

References

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