8wwx

Ube1L acts akin to a mitt, that mediates UbcH8 binding and orchestrates "E1-E2" interactionUbe1L acts akin to a mitt, that mediates UbcH8 binding and orchestrates "E1-E2" interaction

Structural highlights

8wwx is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

UBA7_HUMAN Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.^[1] ^[2]

References

↑ Lenschow DJ, Giannakopoulos NV, Gunn LJ, Johnston C, O'Guin AK, Schmidt RE, Levine B, Virgin HW 4th. Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo. J Virol. 2005 Nov;79(22):13974-83. PMID:16254333 doi:79/22/13974
↑ Zhao C, Hsiang TY, Kuo RL, Krug RM. ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2253-8. PMID:20133869 doi:10.1073/pnas.0909144107

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OCA

[1] Lenschow DJ, Giannakopoulos NV, Gunn LJ, Johnston C, O'Guin AK, Schmidt RE, Levine B, Virgin HW 4th. Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo. J Virol. 2005 Nov;79(22):13974-83. PMID:16254333 doi:79/22/13974

[2] Zhao C, Hsiang TY, Kuo RL, Krug RM. ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2253-8. PMID:20133869 doi:10.1073/pnas.0909144107

[1]

[2]

8wwx

Ube1L acts akin to a mitt, that mediates UbcH8 binding and orchestrates "E1-E2" interactionUbe1L acts akin to a mitt, that mediates UbcH8 binding and orchestrates "E1-E2" interaction

Structural highlights

Function

References

Contents

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8wwx

Ube1L acts akin to a mitt, that mediates UbcH8 binding and orchestrates "E1-E2" interactionUbe1L acts akin to a mitt, that mediates UbcH8 binding and orchestrates "E1-E2" interaction

Structural highlights

Function

References

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