8vdb

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Crystal structure of Bacillus subtilis FabHB, beta-ketoacyl carrier protein synthase IIICrystal structure of Bacillus subtilis FabHB, beta-ketoacyl carrier protein synthase III

Structural highlights

8vdb is a 4 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FABH2_BACSU Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for branched chain acyl-CoA, determining the biosynthesis of branched-chain of fatty acids instead of straight-chain.[1]

References

  1. ↑ Choi KH, Heath RJ, Rock CO. beta-ketoacyl-acyl carrier protein synthase III (FabH) is a determining factor in branched-chain fatty acid biosynthesis. J Bacteriol. 2000 Jan;182(2):365-70. PMID:10629181 doi:10.1128/JB.182.2.365-370.2000

8vdb, resolution 2.40Å

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OCA
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