8smm

Xenopus laevis hyaluronan synthase 1Xenopus laevis hyaluronan synthase 1

Structural highlights

8smm is a 3 chain structure with sequence from Homo sapiens and Xenopus laevis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.2Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HYAS1_XENLA Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate.^[1] ^[2]

References

↑ Rosa F, Sargent TD, Rebbert ML, Michaels GS, Jamrich M, Grunz H, Jonas E, Winkles JA, Dawid IB. Accumulation and decay of DG42 gene products follow a gradient pattern during Xenopus embryogenesis. Dev Biol. 1988 Sep;129(1):114-23. PMID:3410156 doi:10.1016/0012-1606(88)90166-2
↑ Spicer AP, McDonald JA. Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family. J Biol Chem. 1998 Jan 23;273(4):1923-32. PMID:9442026 doi:10.1074/jbc.273.4.1923

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OCA

[1] Rosa F, Sargent TD, Rebbert ML, Michaels GS, Jamrich M, Grunz H, Jonas E, Winkles JA, Dawid IB. Accumulation and decay of DG42 gene products follow a gradient pattern during Xenopus embryogenesis. Dev Biol. 1988 Sep;129(1):114-23. PMID:3410156 doi:10.1016/0012-1606(88)90166-2

[2] Spicer AP, McDonald JA. Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family. J Biol Chem. 1998 Jan 23;273(4):1923-32. PMID:9442026 doi:10.1074/jbc.273.4.1923

[1]

[2]

8smm

Xenopus laevis hyaluronan synthase 1Xenopus laevis hyaluronan synthase 1

Structural highlights

Function

References

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8smm

Xenopus laevis hyaluronan synthase 1Xenopus laevis hyaluronan synthase 1

Structural highlights

Function

References

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