8rix

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Crystal structure of chloroplast FtsY from Arabidopsis thaliana in complex with the alarmone ppGppCrystal structure of chloroplast FtsY from Arabidopsis thaliana in complex with the alarmone ppGpp

Structural highlights

8rix is a 1 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.99Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CFTSY_ARATH Signal recognition particle receptor protein. Binds GTP specifically. The GTPase activity is inhibited by the N-terminus of the protein until binding to the thylakoid membrane. Activates the GTPase activity of FFC/cpSRP54 when bound to the cpSRP complex. Required for light-harvesting chlorophyll a/b-binding protein (LHCP) integration into thylakoids. Might be also functionally linked to the Sec translocation machinery.[1] [2] [3] [4] [5] [6]

References

  1. ↑ Kogata N, Nishio K, Hirohashi T, Kikuchi S, Nakai M. Involvement of a chloroplast homologue of the signal recognition particle receptor protein, FtsY, in protein targeting to thylakoids. FEBS Lett. 1999 Mar 26;447(2-3):329-33. PMID:10214972
  2. ↑ Tu CJ, Schuenemann D, Hoffman NE. Chloroplast FtsY, chloroplast signal recognition particle, and GTP are required to reconstitute the soluble phase of light-harvesting chlorophyll protein transport into thylakoid membranes. J Biol Chem. 1999 Sep 17;274(38):27219-24. PMID:10480939
  3. ↑ Yuan J, Kight A, Goforth RL, Moore M, Peterson EC, Sakon J, Henry R. ATP stimulates signal recognition particle (SRP)/FtsY-supported protein integration in chloroplasts. J Biol Chem. 2002 Aug 30;277(35):32400-4. Epub 2002 Jun 24. PMID:12105232 doi:http://dx.doi.org/10.1074/jbc.M206192200
  4. ↑ Jaru-Ampornpan P, Chandrasekar S, Shan SO. Efficient interaction between two GTPases allows the chloroplast SRP pathway to bypass the requirement for an SRP RNA. Mol Biol Cell. 2007 Jul;18(7):2636-45. Epub 2007 May 2. PMID:17475780 doi:http://dx.doi.org/10.1091/mbc.E07-01-0037
  5. ↑ Asakura Y, Kikuchi S, Nakai M. Non-identical contributions of two membrane-bound cpSRP components, cpFtsY and Alb3, to thylakoid biogenesis. Plant J. 2008 Dec;56(6):1007-17. doi: 10.1111/j.1365-313X.2008.03659.x. Epub 2008, Aug 21. PMID:18764927 doi:http://dx.doi.org/10.1111/j.1365-313X.2008.03659.x
  6. ↑ Marty NJ, Rajalingam D, Kight AD, Lewis NE, Fologea D, Kumar TK, Henry RL, Goforth RL. The membrane-binding motif of the chloroplast signal recognition particle receptor (cpFtsY) regulates GTPase activity. J Biol Chem. 2009 May 29;284(22):14891-903. doi: 10.1074/jbc.M900775200. Epub, 2009 Mar 17. PMID:19293157 doi:http://dx.doi.org/10.1074/jbc.M900775200

8rix, resolution 1.99Å

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