8qic

Structure-based identification of salicylic acid derivatives as malarial threonyl tRNA-synthetase inhibitorsStructure-based identification of salicylic acid derivatives as malarial threonyl tRNA-synthetase inhibitors

Structural highlights 8qic is a 2 chain structure with sequence from Escherichia coli IAI1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.5Å Ligands: , , Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function SYT_ECO8A Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).[HAMAP-Rule:MF_00184]

spinqualitylabelsall models 8qic, resolution 2.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image