8k3t

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S. cerevisiae Chs1 in complex with UDPS. cerevisiae Chs1 in complex with UDP

Structural highlights

8k3t is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.57Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CHS1_YEAST Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer (PubMed:2941152). Required for mitotic division septum formation during adverse conditions (PubMed:2523889).[1] [2]

References

  1. ↑ Cabib E, Sburlati A, Bowers B, Silverman SJ. Chitin synthase 1, an auxiliary enzyme for chitin synthesis in Saccharomyces cerevisiae. J Cell Biol. 1989 May;108(5):1665-72. PMID:2523889 doi:10.1083/jcb.108.5.1665
  2. ↑ Bulawa CE, Slater M, Cabib E, Au-Young J, Sburlati A, Adair WL Jr, Robbins PW. The S. cerevisiae structural gene for chitin synthase is not required for chitin synthesis in vivo. Cell. 1986 Jul 18;46(2):213-25. PMID:2941152 doi:10.1016/0092-8674(86)90738-5

8k3t, resolution 3.57Å

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OCA
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