8jbe

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CryoEM Structure of metazoan Mon1-Ccz1-RMC1 complexCryoEM Structure of metazoan Mon1-Ccz1-RMC1 complex

Structural highlights

8jbe is a 3 chain structure with sequence from Drosophila. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.25Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RMC1_DROME Positive regulator of the Rab7 guanyl-nucleotide exchange activity of the Mon1-Ccz1 complex, possibly by enhancing its endosomal membrane association (PubMed:32391792, PubMed:32499409). As part of the Mon1-Ccz1 complex involved in endolysosomal biogenesis possibly by mediating Rab conversion, the replacement of Rab5 with Rab7 during late endosome maturation (PubMed:32499409).[1] [2]

References

  1. ↑ Langemeyer L, Borchers AC, Herrmann E, Füllbrunn N, Han Y, Perz A, Auffarth K, Kümmel D, Ungermann C. A conserved and regulated mechanism drives endosomal Rab transition. Elife. 2020 May 11;9:e56090. PMID:32391792 doi:10.7554/eLife.56090
  2. ↑ Dehnen L, Janz M, Verma JK, Psathaki OE, Langemeyer L, Fröhlich F, Heinisch JJ, Meyer H, Ungermann C, Paululat A. A trimeric metazoan Rab7 GEF complex is crucial for endocytosis and scavenger function. J Cell Sci. 2020 Jul 9;133(13):jcs247080. PMID:32499409 doi:10.1242/jcs.247080

8jbe, resolution 3.25Å

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OCA
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