8gvh

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Human AE2 in acidic KNO3Human AE2 in acidic KNO3

Structural highlights

8gvh is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.32Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

B3A2_HUMAN The disease may be caused by variants affecting the gene represented in this entry.

Function

B3A2_HUMAN Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity).[UniProtKB:P13808][1] [2]

See Also

References

  1. ↑ Aranda V, Martínez I, Melero S, Lecanda J, Banales JM, Prieto J, Medina JF. Shared apical sorting of anion exchanger isoforms AE2a, AE2b1, and AE2b2 in primary hepatocytes. Biochem Biophys Res Commun. 2004 Jul 2;319(3):1040-6. PMID:15184086 doi:10.1016/j.bbrc.2004.05.080
  2. ↑ Xue JY, Grigelioniene G, Wang Z, Nishimura G, Iida A, Matsumoto N, Tham E, Miyake N, Ikegawa S, Guo L. SLC4A2 Deficiency Causes a New Type of Osteopetrosis. J Bone Miner Res. 2022 Feb;37(2):226-235. PMID:34668226 doi:10.1002/jbmr.4462

8gvh, resolution 3.32Å

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OCA
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