8fx7

Non-ribosomal PCP-C didomain (ester stabilised leucine) acceptor bound stateNon-ribosomal PCP-C didomain (ester stabilised leucine) acceptor bound state

Structural highlights 8fx7 is a 2 chain structure with sequence from Thermobifida fusca YX. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.2Å Ligands: Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q47NR9_THEFY Publication Abstract from PubMed Nonribosomal peptide synthetases produce many important peptide natural products and are centred around carrier proteins (CPs) that deliver intermediates to various catalytic domains. We show that the replacement of CP substrate thioesters by stabilised ester analogues leads to active condensation domain complexes, whereas amide stabilisation generates non-functional complexes. Not always an innocent bystander: the impact of stabilised phosphopantetheine moieties when studying nonribosomal peptide biosynthesis.,Ho YTC, Kaczmarski JA, Tailhades J, Izore T, Steer DL, Schittenhelm RB, Tosin M, Jackson CJ, Cryle MJ Chem Commun (Camb). 2023 Jun 29;59(53):8234-8237. doi: 10.1039/d3cc01578e. PMID:37310188 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

spinqualitylabelsall models 8fx7, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image