8dpe

Crystal structure of ATP-dependent RNA helicase DDX42Crystal structure of ATP-dependent RNA helicase DDX42

Structural highlights

8dpe is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.531Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DDX42_HUMAN ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm.^[1] ^[2]

References

↑ Uhlmann-Schiffler H, Jalal C, Stahl H. Ddx42p--a human DEAD box protein with RNA chaperone activities. Nucleic Acids Res. 2006 Jan 5;34(1):10-22. PMID:16397294 doi:10.1093/nar/gkj403
↑ Uhlmann-Schiffler H, Kiermayer S, Stahl H. The DEAD box protein Ddx42p modulates the function of ASPP2, a stimulator of apoptosis. Oncogene. 2009 May 21;28(20):2065-73. doi: 10.1038/onc.2009.75. Epub 2009 Apr 20. PMID:19377511 doi:10.1038/onc.2009.75

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Uhlmann-Schiffler H, Jalal C, Stahl H. Ddx42p--a human DEAD box protein with RNA chaperone activities. Nucleic Acids Res. 2006 Jan 5;34(1):10-22. PMID:16397294 doi:10.1093/nar/gkj403

[2] Uhlmann-Schiffler H, Kiermayer S, Stahl H. The DEAD box protein Ddx42p modulates the function of ASPP2, a stimulator of apoptosis. Oncogene. 2009 May 21;28(20):2065-73. doi: 10.1038/onc.2009.75. Epub 2009 Apr 20. PMID:19377511 doi:10.1038/onc.2009.75

[1]

[2]

8dpe

Crystal structure of ATP-dependent RNA helicase DDX42Crystal structure of ATP-dependent RNA helicase DDX42

Structural highlights

Function

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

8dpe

Crystal structure of ATP-dependent RNA helicase DDX42Crystal structure of ATP-dependent RNA helicase DDX42

Structural highlights

Function

See Also

References

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Search