8do8

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Crystal structure ATG9 HDIR in complex with the ATG13:ATG101 HORMA dimerCrystal structure ATG9 HDIR in complex with the ATG13:ATG101 HORMA dimer

Structural highlights

8do8 is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.41Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ATGA1_HUMAN Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.[1] [2]

References

  1. ↑ Mercer CA, Kaliappan A, Dennis PB. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. Autophagy. 2009 Jul;5(5):649-62. Epub 2009 Jul 20. PMID:19287211
  2. ↑ Hosokawa N, Sasaki T, Iemura S, Natsume T, Hara T, Mizushima N. Atg101, a novel mammalian autophagy protein interacting with Atg13. Autophagy. 2009 Oct;5(7):973-9. Epub 2009 Oct 18. PMID:19597335

8do8, resolution 2.41Å

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OCA
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