8bhz

The apo-crystal structure of a variant form of the 28-kDa Schistosoma haematobium glutathione transferase in orthorhombic formThe apo-crystal structure of a variant form of the 28-kDa Schistosoma haematobium glutathione transferase in orthorhombic form

Structural highlights

8bhz is a 1 chain structure with sequence from Schistosoma haematobium. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.4Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GST28_SCHHA Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.^[1] GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.^[2]

References

↑ Johnson KA, Angelucci F, Bellelli A, Herve M, Fontaine J, Tsernoglou D, Capron A, Trottein F, Brunori M. Crystal structure of the 28 kDa glutathione S-transferase from Schistosoma haematobium. Biochemistry. 2003 Sep 2;42(34):10084-94. PMID:12939136 doi:http://dx.doi.org/10.1021/bi034449r
↑ Johnson KA, Angelucci F, Bellelli A, Herve M, Fontaine J, Tsernoglou D, Capron A, Trottein F, Brunori M. Crystal structure of the 28 kDa glutathione S-transferase from Schistosoma haematobium. Biochemistry. 2003 Sep 2;42(34):10084-94. PMID:12939136 doi:http://dx.doi.org/10.1021/bi034449r

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OCA

[1] Johnson KA, Angelucci F, Bellelli A, Herve M, Fontaine J, Tsernoglou D, Capron A, Trottein F, Brunori M. Crystal structure of the 28 kDa glutathione S-transferase from Schistosoma haematobium. Biochemistry. 2003 Sep 2;42(34):10084-94. PMID:12939136 doi:http://dx.doi.org/10.1021/bi034449r

[2] Johnson KA, Angelucci F, Bellelli A, Herve M, Fontaine J, Tsernoglou D, Capron A, Trottein F, Brunori M. Crystal structure of the 28 kDa glutathione S-transferase from Schistosoma haematobium. Biochemistry. 2003 Sep 2;42(34):10084-94. PMID:12939136 doi:http://dx.doi.org/10.1021/bi034449r

[1]

[2]

8bhz

The apo-crystal structure of a variant form of the 28-kDa Schistosoma haematobium glutathione transferase in orthorhombic formThe apo-crystal structure of a variant form of the 28-kDa Schistosoma haematobium glutathione transferase in orthorhombic form

Structural highlights

Function

See Also

References

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8bhz

The apo-crystal structure of a variant form of the 28-kDa Schistosoma haematobium glutathione transferase in orthorhombic formThe apo-crystal structure of a variant form of the 28-kDa Schistosoma haematobium glutathione transferase in orthorhombic form

Structural highlights

Function

See Also

References

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