7wi8

Cryo-EM structure of inactive mGlu3 bound to LY341495Cryo-EM structure of inactive mGlu3 bound to LY341495

Structural highlights

7wi8 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[GRM3_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.^[1]

References

↑ Makoff A, Volpe F, Lelchuk R, Harrington K, Emson P. Molecular characterization and localization of human metabotropic glutamate receptor type 3. Brain Res Mol Brain Res. 1996 Aug;40(1):55-63. PMID:8840013

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OCA

[1] Makoff A, Volpe F, Lelchuk R, Harrington K, Emson P. Molecular characterization and localization of human metabotropic glutamate receptor type 3. Brain Res Mol Brain Res. 1996 Aug;40(1):55-63. PMID:8840013

[1]

7wi8

Cryo-EM structure of inactive mGlu3 bound to LY341495Cryo-EM structure of inactive mGlu3 bound to LY341495

Structural highlights

Function

References

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7wi8

Cryo-EM structure of inactive mGlu3 bound to LY341495Cryo-EM structure of inactive mGlu3 bound to LY341495

Structural highlights

Function

References

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