7tlp

Structure of Atopobium parvulum SufS K235RStructure of Atopobium parvulum SufS K235R

Structural highlights 7tlp is a 6 chain structure with sequence from Lancefieldella parvula. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.99Å Ligands: Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function C8W9P2_LANP1 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.[RuleBase:RU004506] Publication Abstract from PubMed Crohn's disease (CD) is characterized by the chronic inflammation of the gastrointestinal tract. A dysbiotic microbiome and a defective immune system are linked to CD, where hydrogen sulfide (H2 S) microbial producers positively correlate with the severity of the disease. Atopobium parvulum is a key H2 S producer from the microbiome of CD patients. In this study, the biochemical characterization of two Atopobium parvulum cysteine desulfurases, ApSufS and ApCsdB, shows that the enzymes are allosterically regulated. Structural analyses reveal that ApSufS forms a dimer with conserved characteristics observed in type II cysteine desulfurases. Four residues surrounding the active site are essential to catalyse cysteine desulfurylation, and a segment of short-chain residues grant access for substrate binding. A better understanding of ApSufS will help future avenues for CD treatment. Structural analysis of Atopobium parvulum SufS cysteine desulfurase linked to Crohn's disease.,Karunakaran G, Yang Y, Tremblay V, Ning Z, Martin J, Belaouad A, Figeys D, Brunzelle JS, Giguere PM, Stintzi A, Couture JF FEBS Lett. 2022 Feb 4. doi: 10.1002/1873-3468.14295. PMID:35122247 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Cysteine desulfurase 3D structures

spinqualitylabelsall models 7tlp, resolution 2.99Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image