7rtk

Structure of the (NIAU)2 complex with N-terminal mutation of ISCU2 Y35D at 2.5 A resolutionStructure of the (NIAU)2 complex with N-terminal mutation of ISCU2 Y35D at 2.5 A resolution

Structural highlights

7rtk is a 4 chain structure with sequence from Escherichia coli and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.5Å
Ligands:	, , , , , , , , , , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

NFS1_HUMAN Severe neonatal lactic acidosis due to NFS1-ISD11 complex deficiency.

Function

NFS1_HUMAN Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor.^[1]

References

↑ Marelja Z, Stocklein W, Nimtz M, Leimkuhler S. A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis. J Biol Chem. 2008 Sep 12;283(37):25178-85. doi: 10.1074/jbc.M804064200. Epub 2008, Jul 23. PMID:18650437 doi:http://dx.doi.org/10.1074/jbc.M804064200

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OCA

[1] Marelja Z, Stocklein W, Nimtz M, Leimkuhler S. A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis. J Biol Chem. 2008 Sep 12;283(37):25178-85. doi: 10.1074/jbc.M804064200. Epub 2008, Jul 23. PMID:18650437 doi:http://dx.doi.org/10.1074/jbc.M804064200

[1]

7rtk

Structure of the (NIAU)2 complex with N-terminal mutation of ISCU2 Y35D at 2.5 A resolutionStructure of the (NIAU)2 complex with N-terminal mutation of ISCU2 Y35D at 2.5 A resolution

Structural highlights

Disease

Function

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References

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7rtk

Structure of the (NIAU)2 complex with N-terminal mutation of ISCU2 Y35D at 2.5 A resolutionStructure of the (NIAU)2 complex with N-terminal mutation of ISCU2 Y35D at 2.5 A resolution

Structural highlights

Disease

Function

See Also

References

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