7r7o

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Structure of methyltransferase domain of Spb1 boudn to SAMStructure of methyltransferase domain of Spb1 boudn to SAM

Structural highlights

7r7o is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.58Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SPB1_YEAST Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Specifically methylates the guanosine in position 2922 of the 25S rRNA at the stage of 27S pre-rRNA maturation. Methylates also the uridine in position 2921 in the absence of methylation of this residue guided by snoRNA snR52 at the stage of 35S pre-rRNA maturation.[HAMAP-Rule:MF_03163][1] [2] [3]

References

  1. ↑ Kressler D, Rojo M, Linder P, Cruz J. Spb1p is a putative methyltransferase required for 60S ribosomal subunit biogenesis in Saccharomyces cerevisiae. Nucleic Acids Res. 1999 Dec 1;27(23):4598-608. PMID:10556316
  2. ↑ Bonnerot C, Pintard L, Lutfalla G. Functional redundancy of Spb1p and a snR52-dependent mechanism for the 2'-O-ribose methylation of a conserved rRNA position in yeast. Mol Cell. 2003 Nov;12(5):1309-15. PMID:14636587
  3. ↑ Lapeyre B, Purushothaman SK. Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage. Mol Cell. 2004 Nov 19;16(4):663-9. PMID:15546625 doi:http://dx.doi.org/S1097276504006483

7r7o, resolution 1.58Å

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OCA
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