7moq

The structure of the Tetrahymena thermophila outer dynein arm on doublet microtubuleThe structure of the Tetrahymena thermophila outer dynein arm on doublet microtubule

Structural highlights 7moq is a 12 chain structure with sequence from Tetrahymena thermophila CU428. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 8Å Ligands: , , , , Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q22A67_TETTS Publication Abstract from PubMed Cilia are thin microtubule-based protrusions of eukaryotic cells. The swimming of ciliated protists and sperm cells is propelled by the beating of cilia. Cilia propagate the flow of mucus in the trachea and protect the human body from viral infections. The main force generators of ciliary beating are the outer dynein arms (ODAs) which attach to the doublet microtubules. The bending of cilia is driven by the ODAs' conformational changes caused by ATP hydrolysis. Here, we report the native ODA complex structure attaching to the doublet microtubule by cryo-electron microscopy. The structure reveals how the ODA complex is attached to the doublet microtubule via the docking complex in its native state. Combined with coarse-grained molecular dynamic simulations, we present a model of how the attachment of the ODA to the doublet microtubule induces remodeling and activation of the ODA complex. Remodeling and activation mechanisms of outer arm dyneins revealed by cryo-EM.,Kubo S, Yang SK, Black CS, Dai D, Valente-Paterno M, Gaertig J, Ichikawa M, Bui KH EMBO Rep. 2021 Sep 6;22(9):e52911. doi: 10.15252/embr.202152911. Epub 2021 Aug 2. PMID:34338432 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Dynein 3D structures Thioredoxin 3D structures

spinqualitylabelsall models 7moq, resolution 8.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image