6zqc

Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Pre-A1Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Pre-A1

Structural highlights

6zqc is a 12 chain structure with sequence from Saccharomyces cerevisiae S288C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.8Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FBRL_YEAST S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (PubMed:1825809). Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Involved in the biogenesis of the 18S rRNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239).^[1] ^[2] ^[3]

References

↑ Tollervey D, Lehtonen H, Carmo-Fonseca M, Hurt EC. The small nucleolar RNP protein NOP1 (fibrillarin) is required for pre-rRNA processing in yeast. EMBO J. 1991 Mar;10(3):573-83. PMID:1825809
↑ Tessarz P, Santos-Rosa H, Robson SC, Sylvestersen KB, Nelson CJ, Nielsen ML, Kouzarides T. Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. Nature. 2014 Jan 23;505(7484):564-8. doi: 10.1038/nature12819. Epub 2013 Dec 18. PMID:24352239 doi:http://dx.doi.org/10.1038/nature12819
↑ Schimmang T, Tollervey D, Kern H, Frank R, Hurt EC. A yeast nucleolar protein related to mammalian fibrillarin is associated with small nucleolar RNA and is essential for viability. EMBO J. 1989 Dec 20;8(13):4015-24. PMID:2686980

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OCA

[1] Tollervey D, Lehtonen H, Carmo-Fonseca M, Hurt EC. The small nucleolar RNP protein NOP1 (fibrillarin) is required for pre-rRNA processing in yeast. EMBO J. 1991 Mar;10(3):573-83. PMID:1825809

[2] Tessarz P, Santos-Rosa H, Robson SC, Sylvestersen KB, Nelson CJ, Nielsen ML, Kouzarides T. Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. Nature. 2014 Jan 23;505(7484):564-8. doi: 10.1038/nature12819. Epub 2013 Dec 18. PMID:24352239 doi:http://dx.doi.org/10.1038/nature12819

[3] Schimmang T, Tollervey D, Kern H, Frank R, Hurt EC. A yeast nucleolar protein related to mammalian fibrillarin is associated with small nucleolar RNA and is essential for viability. EMBO J. 1989 Dec 20;8(13):4015-24. PMID:2686980

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[2]

[3]

6zqc

Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Pre-A1Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Pre-A1

Structural highlights

Function

See Also

References

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6zqc

Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Pre-A1Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Pre-A1

Structural highlights

Function

See Also

References

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