6xpe

Cryo-EM structure of human ZnT8 WT, in the presence of zinc, determined in outward-facing conformationCryo-EM structure of human ZnT8 WT, in the presence of zinc, determined in outward-facing conformation

Structural highlights

6xpe is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 4.1Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ZNT8_HUMAN Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.^[1]

References

↑ Chimienti F, Devergnas S, Pattou F, Schuit F, Garcia-Cuenca R, Vandewalle B, Kerr-Conte J, Van Lommel L, Grunwald D, Favier A, Seve M. In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. J Cell Sci. 2006 Oct 15;119(Pt 20):4199-206. doi: 10.1242/jcs.03164. Epub 2006, Sep 19. PMID:16984975 doi:http://dx.doi.org/10.1242/jcs.03164

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OCA

[1] Chimienti F, Devergnas S, Pattou F, Schuit F, Garcia-Cuenca R, Vandewalle B, Kerr-Conte J, Van Lommel L, Grunwald D, Favier A, Seve M. In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. J Cell Sci. 2006 Oct 15;119(Pt 20):4199-206. doi: 10.1242/jcs.03164. Epub 2006, Sep 19. PMID:16984975 doi:http://dx.doi.org/10.1242/jcs.03164

[1]

6xpe

Cryo-EM structure of human ZnT8 WT, in the presence of zinc, determined in outward-facing conformationCryo-EM structure of human ZnT8 WT, in the presence of zinc, determined in outward-facing conformation

Structural highlights

Function

References

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6xpe

Cryo-EM structure of human ZnT8 WT, in the presence of zinc, determined in outward-facing conformationCryo-EM structure of human ZnT8 WT, in the presence of zinc, determined in outward-facing conformation

Structural highlights

Function

References

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