6wn9

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Structure of Staphylococcus aureus peptidoglycan O-acetyltransferase A (OatA) C-terminal catalytic domain, Zn-boundStructure of Staphylococcus aureus peptidoglycan O-acetyltransferase A (OatA) C-terminal catalytic domain, Zn-bound

Structural highlights

6wn9 is a 2 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.55Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

OATA_STAA8 Responsible for O-acetylation at the C(6)-hydroxyl group of N-acetylmuramyl residues, forming the corresponding N,6-O-diacetylmuramic acid of the peptidoglycan (PubMed:15661003, PubMed:32350117). O-acetylation of the peptidoglycan is the major determinant for lysozyme resistance (PubMed:15661003).[1] [2]

References

  1. ↑ Bera A, Herbert S, Jakob A, Vollmer W, Götz F. Why are pathogenic staphylococci so lysozyme resistant? The peptidoglycan O-acetyltransferase OatA is the major determinant for lysozyme resistance of Staphylococcus aureus. Mol Microbiol. 2005 Feb;55(3):778-87. PMID:15661003 doi:10.1111/j.1365-2958.2004.04446.x
  2. ↑ Jones CS, Sychantha D, Howell PL, Clarke AJ. Structural basis for the O-acetyltransferase function of the extracytoplasmic domain of OatA from Staphylococcus aureus. J Biol Chem. 2020 Apr 29. pii: RA120.013108. doi: 10.1074/jbc.RA120.013108. PMID:32350117 doi:http://dx.doi.org/10.1074/jbc.RA120.013108

6wn9, resolution 1.55Å

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OCA
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