6u5o

Structure of the Human Metapneumovirus Polymerase bound to the phosphoprotein tetramerStructure of the Human Metapneumovirus Polymerase bound to the phosphoprotein tetramer

6u5o, resolution 3.70Å Show:Asymmetric Unit Biological Assembly Structural highlights 6u5o is a 5 chain structure with sequence from Human metapneumovirus CAN97-83. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.7Å Experimental data: Check Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function L_HMPVC Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular protein N concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals (By similarity). See Also RNA polymerase 3D structures