6rz0

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Crystal structure of Escherichia coli Glyoxalase IICrystal structure of Escherichia coli Glyoxalase II

Structural highlights

6rz0 is a 1 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.1Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GLO2_ECOLI Type II glyoxalase that catalyzes the hydrolysis of (R)-S-lactoylglutathione to (R)-lactate and glutathione (PubMed:25670698, PubMed:17196158). Is more efficient than the isozyme GloC, and plays a major contribution to methylglyoxal (MG) detoxification in E.coli (PubMed:25670698). The two isoenzymes have additive effects and ensure maximal MG degradation (PubMed:25670698).[1] [2]

See Also

References

  1. ↑ O'Young J, Sukdeo N, Honek JF. Escherichia coli glyoxalase II is a binuclear zinc-dependent metalloenzyme. Arch Biochem Biophys. 2007 Mar 1;459(1):20-6. PMID:17196158 doi:10.1016/j.abb.2006.11.024
  2. ↑ Reiger M, Lassak J, Jung K. Deciphering the role of the type II glyoxalase isoenzyme YcbL (GlxII-2) in Escherichia coli. FEMS Microbiol Lett. 2015 Jan;362(2):1-7. PMID:25670698 doi:10.1093/femsle/fnu014

6rz0, resolution 1.10Å

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OCA
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