6pkv

Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C4 symmetryCryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C4 symmetry

6pkv, resolution 4.30Å Show:Asymmetric Unit Biological Assembly Structural highlights 6pkv is a 4 chain structure with sequence from Danio rerio. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 4.3Å Experimental data: Check Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function TRPM2_DANRE Nonselective, voltage-independent cation channel that mediates Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP-ribose to the cytoplasmic N-terminal region causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening.